Research Article
Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats
Dina R. S. Gad El-Karim
Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Alexandria University, Egypt.
JVMR. 2019; 26(2): 235-246
Abstract
The present study was designed to evaluate the probable ameliorative
effect of dandelion extract against doxorubicin hemato-cardiotoxicity. To
accomplish this study, four groups of male albino rats (n=7) were used as
follow, Group I: served as a control group, Group II: received dandelion
extract (200 mg/ kg), Group III: received doxorubicin (2.5 mg/kg) and Group
IV: received dandelion extract and doxorubicin identically to groups II and III.
Doxorubicin was administrated 3times/week for two consecutive weeks, while
dandelion extract was administrated daily for two consecutive weeks before
doxorubicin administration and continued during doxorubicin treatment. The
results illuminated that, administration of doxorubicin has a deleterious effect
on both of blood cellular components and cardiac tissues, which was indicated
by significant pancytopenia (decrease in all blood cell types), elevated serum
cardiac enzymes activity (CK-MB and LDH), increased serum level of cardiacrelated proteins (troponin I, atrial natriuretic peptide (ANP) and B-type
natriuretic peptide (BNP) with a depletion of cardiac tissues antioxidant (GSH,
and SOD enzyme) and elevated lipid peroxide (MDA) level in this tissues. Coadministration of dandelion extract with doxorubicin significantly alleviated its
hemato-cardiotoxic effect which was reflected positively on hematobiochemical changes and cardiac histopathological alterations.
Keywords
ANP, BNP, Dandelion, Doxorubicin, Hemato-cardiotoxicity, Rats.
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