Research Article

Subcutaneous pharmacokinetic interaction of tulathromycin With flunixin meglumine in goats

M. Adam, M. A. Tohamy, S.E. El-Sadek and Abeer M. Radi
Pharmacology Department, Faculty of Veterinary Medicine, Beni-Suef University, Egypt

Abstract

  The pharmacokinetic aspects of tulathromycin(2.5 mg/kg) administered alone and in combination with flunixin meglumine (2.2 mg/kg) after a single subcutaneous (SC) administration, werestudied in clinically healthy goats. The animals were divided into two groups: the 1^st group was given tulathromycin alone and the 2^nd group was given tulathromycin concurrently with flunixin meglumine. Serum concentrations of tulathromycin were determined using microbiological assay method. Tulathromycin was rapidly absorbed with a half-life of absorption (t(₀.₅)_ab) of 0.54 h and the peak plasma concentration (C_max) was 3.7ug/ml was attained after 0.98 h (T_max). Flunixin significantly altered the pharmacokinetics of tulathromycin by increasing its absorption and delay its elimination from body where t₀.₅(_ab)were 0.54 and0.34 h and the elimination half-lives (t₀.₅(_el)) were 1.35 and 1.8 h, for alone and combination groups, respectively. Significant decreases (39.8%) in the area under the curve (AUC) and (22.6%) in the elimination rate constant (Kel) from the central compartment were found following co­administration with flunixin compared with administration of tulathromycin alone. It was concluded that the combination of tulathromycin and flunixin negatively altered the kinetics of tulathromycin.

Keywords

Pharmacokinetics, Tulathromycin, Flunixin, Subcutaneous, Goats.